After a one season role on the drama Profiler, she was cast as a series regular on the award-winning series, Once Again, in which she appeared for four seasons. Her first major screen role was Digging to China, with Kevin Bacon, followed by Practical Magic, with Sandra Bullock and Nicole Kidman. In 2002, she made her teenage debut as a leading film actress in Little Secrets, and played a supporting role in the sci-fi drama, S1m0ne, starring Al Pacino. The following year, in addition to her role in Thirteen, Wood played the kidnapped daughter of Cate Blanchett and Tommy Lee Jones in Ron Howard’s Missing. Her subsequent films include The Upside of Anger, Pretty Persuasion (2005 Sundance Grand Jury Prize winner), Down in the Valley, Running with Scissors and King of California. She displayed her singing talents in 2007 with her role as Lucy in Julie Taymor’s Across the Universe, set to the songs of the Beatles. She then voiced the role of an alien in Battle for Terra, and starred opposite Uma Thurman in The Life Before Her Eyes, before playing Stephanie in The Wrestler and Melodie in Woody Allen's Whatever Works.
In 2010, she was seen in Robert Redford’s, The Conspirator in which she starred alongside James McAvoy and Robin Wright. She also appeared as Queen Sophie-Ann Leclerq in the critically acclaimed HBO show, True Blood. Evan starred in The Ides of March directed by and starring George Clooney. The cast also included Ryan Gosling, Marisa Tomei, Paul Giamatti, Philip Seymour Hoffman. Evan was most recently seen in Charlie Countryman alongside Shia LaBeouf and Mads Mikeelsen, in A Case of You alongside Justin Long, and opposite Scott Speedman in Andrew Fleming’s Barefoot.
Evan’s upcoming films include Into the Forest with Ellen Page based on Jean Hegland’s apocalyptic novel about two sisters struggling to survive in the wilderness after society collapses, Joe Berlinger’s film adaptation of Facing the Wind based on the true-crime story of Bob Rowe, and Gerardo Naranjo’s Viena and the Fantomes opposite Dakota Fanning and Zoe Kravitz. Evan Rachel Wood most recently wrapped voicing a character in George Lucas’ new film Strange Magic.
Most recently, Evan teamed up with actor/musician Zach Villa, to form Rebel and a Basketcase, an alternative/electronic pop band. They debuted their first track “Oh Yeah” this June.