Nina K. Noble was born in New York, and raised on film sets in various U.S. cities. In 1984, after many years as a production assistant on movies, television and commercials, she joined the Directors Guild of America as a Second Assistant Director. The next ten years were spent working as a freelance Assistant Director on feature films, traveling throughout the U.S. with many prominent directors, including Alan Parker, Paul Mazursky, Ron Shelton, Stephen Frears, Paul Verhoeven and Ivan Reitman.
In 1995, Noble began producing and production managing TV pilots and made-for-TV movies, primarily for The Levinson/Fontana Company in New York. This association led to a meeting with David Simon in 1999. Simon was then developing 'The Corner' for HBO, and hired Noble as producer. This began a successful collaboration which continued with 'The Wire,' 'Generation Kill,' and now 'Treme.'