But one thing will be different. For the first time, it is Matthew, not his big brother Ricky, in the full glare of the spotlight. The other problem is this: The fighter sharing it with him is a streaking, unbeaten prospect who is already being groomed for greatness.
After more than ten years in the shadows, and against the wishes of his camp, the younger Hatton is stepping up a division to fight Alvarez for the WBC super welterweight championship given up by Manny Pacquiao, the man who effectively ended his brother's career nearly two years ago.
Not surprisingly, Hatton is a long shot with the oddsmakers - as high as 6-1 against in Britain - and an even bigger outsider in America despite six previous appearances in the U.S.
But the 29-year-old from Manchester, England, says he is confident he can "tear the script up." He claims speed and workrate hold the key to him pulling off a victory that would rank among the biggest upsets of recent years.
"I'm on a roll at the moment," said Hatton, 41-4-2 (16), just before flying out to the States from London. "I've won the European [welterweight] title and successfully defended it twice. A world title opportunity was the next stage. It's quite a surprise that I'm getting it at junior middleweight, but it's a good opportunity and I'm ready to take it."
His most vocal supporter will be his brother, who is co-promoting the fight under the Hatton Promotions banner, but the younger Hatton insists he has never felt any pressure to match his sibling's achievements.
"Ricky's been a fantastic fighter, but it's never really been my ambition to emulate him or other fighters," admitted Hatton. "I just want to be the best I can possibly be. It's always been my ambition to become a world champion. It's within touching distance now, so I can't wait for it."