The DeMoe Family: Early-Onset Alzheimer's Genetics
(Approx. 25:43 min) Featuring: Bill Klunk, MD, Ph.D, and Chester Mathis, Ph.D-University of Pittsburgh School of Medicine; Steven DeKosky, MD-University of Pittsburgh School of Medicine (currently at University of Virginia School of Medicine)
Using breakthrough imaging technology, researchers at the University of Pittsburgh are learning how Alzheimer's pathology progresses in people with the rare, early-onset form of Alzheimer's, whose genetic mutation determines that they will get the disease. The film follows the DeMoe family, five of whose six children carry the mutation, and we learn about the emotional and personal toll it takes.
Momentum in Science: The Supplementary Series
- Understanding and Attacking Alzheimer's 12 min
- How Far We Have Come in Alzheimer's Research 15 min
- Identifying Mild Cognitive Impairment 20 min
- The Role of Genetics in Alzheimer's 12 min
- Advances in Brain Imaging 11 min
- Looking Into the Future of Alzheimer's 6 min
- The Connection Between Insulin and Alzheimer's 21 min
- Inflammation, the Immune System, and Alzheimer's 29 min
- The Benefit of Diet and Exercise in Alzheimer's 16 min
- Cognitive Reserve: What the Religious Orders Study is Revealing about Alzheimer's 20 min
- Searching for an Alzheimer's Cure: The Story of Flurizan 30 min
- The Pulse of Drug Development 15 min
- The DeMoe Family: Early-Onset Alzheimer's Genetics 25 min
- The Nanney/Felts Family: Late-Onset Alzheimer's Genetics 20 min
- The Quest for Biomarkers 17 min
- Hope in Science
Scientists have made great advances in understanding the cause, diagnosis, and possible treatments of Alzheimer's disease. Find out more.
Download the Viewer's Guides
For Momentum in Science
Alzheimer's Disease Genetics Fact Sheet:
Brief overview of what science has learned about Alzheimer's genes.
Connect with Alzheimer's Research
Find out how you can participate in clinical trials or studies, find a research center, or get up-to-date information at 1-800-438-4380.
The Alzheimer's Association 24/7 Helpline provides reliable information and support to all those who need assistance. Call us toll-free anytime day or night at 1-800-272-3900.
Create A Tribute
Honor someone you care about and share your stories by contributing to The Tribute Wall on Facebook.
The Alzheimer's Association message boards and chat rooms are your online communication forum. Share your thoughts and experiences, query your colleagues, and make new friends.
- Early-onset Alzheimer's disease is a rare form of AD that usually affects people between ages thirty and sixty. Some cases of early-onset AD, called familial AD (FAD), run in families.
- Late-onset Alzheimer's disease is the most common form of AD. It occurs in people age 60 and older. Scientists studying the genetics of AD have found that the mutations seen in early-onset AD are not involved in this form of the disease.
- 54% of the adult U.S. population has been touched by Alzheimer's. Read more.